Cargando…

Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

Tumor heterogeneity can be traced back to a small subset of cancer stem cells (CSCs), which can be derived from a single stem cell and show chemoresistance. Recent studies showed that CSCs are sensitive to mitochondrial targeting antibiotics such as doxycycline. However, little is known about how ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumoto, Takashi, Uchiumi, Takeshi, Monji, Keisuke, Yagi, Mikako, Setoyama, Daiki, Amamoto, Rie, Matsushima, Yuichi, Shiota, Masaki, Eto, Masatoshi, Kang, Dongchon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868058/
https://www.ncbi.nlm.nih.gov/pubmed/29184058
http://dx.doi.org/10.1038/s41389-017-0009-3

Ejemplares similares