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Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice
Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet, against metabolic and cardiovascular diseases, can be attributed to the action of polyphenolic components of extra-virgin olive oil (EVOO). Here, we evaluated the protective effects of oleacein, one of the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868215/ https://www.ncbi.nlm.nih.gov/pubmed/29615982 http://dx.doi.org/10.3389/fendo.2018.00116 |
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author | Lombardo, Giovanni Enrico Lepore, Saverio Massimo Morittu, Valeria Maria Arcidiacono, Biagio Colica, Carmela Procopio, Antonio Maggisano, Valentina Bulotta, Stefania Costa, Nicola Mignogna, Chiara Britti, Domenico Brunetti, Antonio Russo, Diego Celano, Marilena |
author_facet | Lombardo, Giovanni Enrico Lepore, Saverio Massimo Morittu, Valeria Maria Arcidiacono, Biagio Colica, Carmela Procopio, Antonio Maggisano, Valentina Bulotta, Stefania Costa, Nicola Mignogna, Chiara Britti, Domenico Brunetti, Antonio Russo, Diego Celano, Marilena |
author_sort | Lombardo, Giovanni Enrico |
collection | PubMed |
description | Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet, against metabolic and cardiovascular diseases, can be attributed to the action of polyphenolic components of extra-virgin olive oil (EVOO). Here, we evaluated the protective effects of oleacein, one of the most abundant secoiridoids in EVOO, on the damages/metabolic alterations caused by high-fat diet (HFD) in male C57BL/6JolaHsd mice. After 5 weeks of treatment with 20 mg/kg of oleacein, body weight, glycemia, insulinemia, serum lipids, and histologic examination of liver tissue indicated a protective action of oleacein against abdominal fat accumulation, weight gain, and liver steatosis, with improvement of insulin-dependent glucose and lipid metabolism. Both serum parameters and hepatic histologic examination were altered in mice fed with HFD. By contrast, in the animals that received oleacein, plasma glucose, cholesterol and triglyceride serum levels, and liver histology were similar to controls fed with normocaloric diet. In addition, protein levels of FAS, SREBP-1, and phospho-ERK in liver were positively modulated by oleacein, indicating an improvement in liver insulin sensitivity. In a group of obese mice, treatment with oleacein determined a light, but still significant reduction of the increase in body weight, mainly due to lesser liver steatosis enlargement, associated with reduced levels of SREBP-1 and phospho-ERK and lower levels of total serum cholesterol; in these animals, altered plasma glucose and triglyceride serum levels were not reverted by oleacein. These results indicate that HFD-related hepatic insulin resistance may be partially prevented by oral administration of oleacein, suggesting a protective role of this nutraceutical against diet-dependent metabolic alterations. Additional studies are necessary to check whether oleacein can be used as an adjuvant to improve insulin sensitivity in humans. |
format | Online Article Text |
id | pubmed-5868215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58682152018-04-03 Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice Lombardo, Giovanni Enrico Lepore, Saverio Massimo Morittu, Valeria Maria Arcidiacono, Biagio Colica, Carmela Procopio, Antonio Maggisano, Valentina Bulotta, Stefania Costa, Nicola Mignogna, Chiara Britti, Domenico Brunetti, Antonio Russo, Diego Celano, Marilena Front Endocrinol (Lausanne) Endocrinology Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet, against metabolic and cardiovascular diseases, can be attributed to the action of polyphenolic components of extra-virgin olive oil (EVOO). Here, we evaluated the protective effects of oleacein, one of the most abundant secoiridoids in EVOO, on the damages/metabolic alterations caused by high-fat diet (HFD) in male C57BL/6JolaHsd mice. After 5 weeks of treatment with 20 mg/kg of oleacein, body weight, glycemia, insulinemia, serum lipids, and histologic examination of liver tissue indicated a protective action of oleacein against abdominal fat accumulation, weight gain, and liver steatosis, with improvement of insulin-dependent glucose and lipid metabolism. Both serum parameters and hepatic histologic examination were altered in mice fed with HFD. By contrast, in the animals that received oleacein, plasma glucose, cholesterol and triglyceride serum levels, and liver histology were similar to controls fed with normocaloric diet. In addition, protein levels of FAS, SREBP-1, and phospho-ERK in liver were positively modulated by oleacein, indicating an improvement in liver insulin sensitivity. In a group of obese mice, treatment with oleacein determined a light, but still significant reduction of the increase in body weight, mainly due to lesser liver steatosis enlargement, associated with reduced levels of SREBP-1 and phospho-ERK and lower levels of total serum cholesterol; in these animals, altered plasma glucose and triglyceride serum levels were not reverted by oleacein. These results indicate that HFD-related hepatic insulin resistance may be partially prevented by oral administration of oleacein, suggesting a protective role of this nutraceutical against diet-dependent metabolic alterations. Additional studies are necessary to check whether oleacein can be used as an adjuvant to improve insulin sensitivity in humans. Frontiers Media S.A. 2018-03-19 /pmc/articles/PMC5868215/ /pubmed/29615982 http://dx.doi.org/10.3389/fendo.2018.00116 Text en Copyright © 2018 Lombardo, Lepore, Morittu, Arcidiacono, Colica, Procopio, Maggisano, Bulotta, Costa, Mignogna, Britti, Brunetti, Russo and Celano. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Lombardo, Giovanni Enrico Lepore, Saverio Massimo Morittu, Valeria Maria Arcidiacono, Biagio Colica, Carmela Procopio, Antonio Maggisano, Valentina Bulotta, Stefania Costa, Nicola Mignogna, Chiara Britti, Domenico Brunetti, Antonio Russo, Diego Celano, Marilena Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice |
title | Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice |
title_full | Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice |
title_fullStr | Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice |
title_full_unstemmed | Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice |
title_short | Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice |
title_sort | effects of oleacein on high-fat diet-dependent steatosis, weight gain, and insulin resistance in mice |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868215/ https://www.ncbi.nlm.nih.gov/pubmed/29615982 http://dx.doi.org/10.3389/fendo.2018.00116 |
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