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Dimerization of sortilin regulates its trafficking to extracellular vesicles

Extracellular vesicles (EVs) play a critical role in intercellular communication by transferring microRNAs, lipids, and proteins to neighboring cells. Sortilin, a sorting receptor that directs target proteins to the secretory or endocytic compartments of cells, is found in both EVs and cells. In man...

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Detalles Bibliográficos
Autores principales: Itoh, Shinsuke, Mizuno, Ken, Aikawa, Masanori, Aikawa, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868269/
https://www.ncbi.nlm.nih.gov/pubmed/29382723
http://dx.doi.org/10.1074/jbc.RA117.000732