Cargando…

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion

Despite the important role of apolipoprotein E (apoE) secretion from astrocytes in brain lipid metabolism and the strong association of apoE4, one of the human apoE isoforms, with sporadic and late onset forms of Alzheimer’s disease (AD) little is known about the regulation of astrocytic apoE. Utili...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dresselhaus, Erica, Duerr, James M., Vincent, Fabien, Sylvain, Emily K., Beyna, Mercedes, Lanyon, Lorraine F., LaChapelle, Erik, Pettersson, Martin, Bales, Kelly R., Ramaswamy, Gayathri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868809/ https://www.ncbi.nlm.nih.gov/pubmed/29579087 http://dx.doi.org/10.1371/journal.pone.0194661

Ejemplares similares

ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes
por: Keable, Abby, et al.
Publicado: (2020)

Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation
por: Saroja, Sivaprakasam R., et al.
Publicado: (2022)

HDAC6 Regulates LPS-Tolerance in Astrocytes
por: Beurel, Eléonore
Publicado: (2011)

Class IIa HDACs in myelination
por: Velasco-Aviles, Sergio, et al.
Publicado: (2018)

ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis
por: Staurenghi, Erica, et al.
Publicado: (2022)

Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function
por: Zhong, Ning, et al.
Publicado: (2009)

“My Fibro Family!” A qualitative analysis of facebook fibromyalgia support groups’ discussion content
por: Crump, Lyndsay, et al.
Publicado: (2022)

“Don't need [therapy]! Not necessary, that's what we're for!”: Does content from fibromyalgia Facebook peer support groups emulate psychological flexibility principles?
por: Crump, Lyndsay, et al.
Publicado: (2023)

APOE expression and secretion are modulated by mitochondrial dysfunction
por: Wynne, Meghan E, et al.
Publicado: (2023)

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes
por: Schmukler, Eran, et al.
Publicado: (2020)

APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes
por: Eran, Schmukler, et al.
Publicado: (2021)

Astrocytic apoE4 and tau: Deadly combination for neurons
por: Chakrabarty, Paramita, et al.
Publicado: (2021)

Regulating the Regulators: The Post-Translational Code of Class I HDAC1 and HDAC2
por: Segré, Chiara V., et al.
Publicado: (2011)

Identifying the features of partner acceptance of arthritis: A qualitative analysis
por: Gullickson, Kirsten M., et al.
Publicado: (2018)

APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes
por: Lee, Sangderk, et al.
Publicado: (2023)

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9
por: Lenoir, Olivia, et al.
Publicado: (2011)

Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes
por: Bencharif, Karima, et al.
Publicado: (2010)

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
por: Qi, Guoyuan, et al.
Publicado: (2021)

APOE4 derived from astrocytes leads to blood–brain barrier impairment
por: Jackson, Rosemary J, et al.
Publicado: (2021)

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes
por: Nebbioso, Angela, et al.
Publicado: (2009)

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
por: Dai, Yan, et al.
Publicado: (2008)

Discovering HDAC class II selective inhibitors by multidisciplinary approach
por: Lorenzi, S, et al.
Publicado: (2011)

Physiological Roles of Class I HDAC Complex and Histone Demethylase
por: Hayakawa, Tomohiro, et al.
Publicado: (2011)

Class II and IV HDACs function as inhibitors of osteoclast differentiation
por: Blixt, Nicholas C., et al.
Publicado: (2017)

Ring size changes in the development of class I HDAC inhibitors
por: Cho, Er-Chieh, et al.
Publicado: (2021)

Ellagic Acid Suppresses ApoB Secretion and Enhances ApoA-1 Secretion from Human Hepatoma Cells, HepG2
por: Ieda, Ayana, et al.
Publicado: (2021)

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6
por: Traoré, Mohamed D. M., et al.
Publicado: (2017)

HDAC Screening Identifies the HDAC Class I Inhibitor Romidepsin as a Promising Epigenetic Drug for Biliary Tract Cancer
por: Mayr, Christian, et al.
Publicado: (2021)

Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors
por: Schäker‐Hübner, Linda, et al.
Publicado: (2022)

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease
por: Fernandez, Celia G., et al.
Publicado: (2019)

Lipolysis-Stimulated Lipoprotein Receptor Acts as Sensor to Regulate ApoE Release in Astrocytes
por: Herzine, Ameziane, et al.
Publicado: (2022)

Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat Is Associated with IL-6/Stat3 Signaling in Ischemic Heart Failure
por: Nural-Guvener, Hikmet, et al.
Publicado: (2015)

Effects of a Comprehensive, Multiple Risky Behavior Prevention Program on High School Students
por: Collier, Crystal, et al.
Publicado: (2016)

HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation
por: Ye, Jinwang, et al.
Publicado: (2022)

ApoE isoforms differentially regulates cleavage and secretion of BDNF
por: Sen, Abhik, et al.
Publicado: (2017)

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2
por: Jayathilaka, Nimanthi, et al.
Publicado: (2012)

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
por: Watson, Peter J., et al.
Publicado: (2016)

HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma
por: Souri, Zahra, et al.
Publicado: (2020)

Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs)
por: Luo, Yuxiang, et al.
Publicado: (2020)

Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes
por: Jovičić, Ana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sf7obmpq83ofqusqj9pgiiurcn