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Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine
The natural alkaloid berberine has been ascribed numerous health benefits including lipid and cholesterol reduction and improved insulin sensitivity in diabetics. However, oral (PO) administration of berberine is hindered by poor bioavailability and increasing dose often elicits gastro-intestinal si...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868852/ https://www.ncbi.nlm.nih.gov/pubmed/29579096 http://dx.doi.org/10.1371/journal.pone.0194979 |