Mechanical strain regulates the Hippo pathway in Drosophila

Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1), the sole Drosophila homolog of which is named Yorkie (Yki). In mammalian cells in culture, artificial mechanical forces induce nuclear translocation of YAP and TAZ. Here, we sh...

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Detalles Bibliográficos
Autores principales: Fletcher, Georgina C., Diaz-de-la-Loza, Maria-del-Carmen, Borreguero-Muñoz, Nerea, Holder, Maxine, Aguilar-Aragon, Mario, Thompson, Barry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868995/
https://www.ncbi.nlm.nih.gov/pubmed/29440303
http://dx.doi.org/10.1242/dev.159467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868995/
https://www.ncbi.nlm.nih.gov/pubmed/29440303
http://dx.doi.org/10.1242/dev.159467

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