Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses

Viral metagenomics, modeling of protein structure, and manipulation of viral genetics are key approaches that have laid the foundations of our understanding of coronavirus biology. In this review, we discuss the major advances each method has provided and discuss how future studies should leverage t...

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Detalles Bibliográficos
Autores principales: Johnson, Bryan A., Graham, Rachel L., Menachery, Vineet D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869085/
https://www.ncbi.nlm.nih.gov/pubmed/29279138
http://dx.doi.org/10.1016/j.virol.2017.12.009
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author Johnson, Bryan A.
Graham, Rachel L.
Menachery, Vineet D.
author_facet Johnson, Bryan A.
Graham, Rachel L.
Menachery, Vineet D.
author_sort Johnson, Bryan A.
collection PubMed
description Viral metagenomics, modeling of protein structure, and manipulation of viral genetics are key approaches that have laid the foundations of our understanding of coronavirus biology. In this review, we discuss the major advances each method has provided and discuss how future studies should leverage these strategies synergistically to answer novel questions.
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spelling pubmed-58690852019-04-01 Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses Johnson, Bryan A. Graham, Rachel L. Menachery, Vineet D. Virology Article Viral metagenomics, modeling of protein structure, and manipulation of viral genetics are key approaches that have laid the foundations of our understanding of coronavirus biology. In this review, we discuss the major advances each method has provided and discuss how future studies should leverage these strategies synergistically to answer novel questions. Elsevier Inc. 2018-04 2017-12-24 /pmc/articles/PMC5869085/ /pubmed/29279138 http://dx.doi.org/10.1016/j.virol.2017.12.009 Text en © 2017 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Johnson, Bryan A.
Graham, Rachel L.
Menachery, Vineet D.
Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
title Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
title_full Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
title_fullStr Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
title_full_unstemmed Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
title_short Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
title_sort viral metagenomics, protein structure, and reverse genetics: key strategies for investigating coronaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869085/
https://www.ncbi.nlm.nih.gov/pubmed/29279138
http://dx.doi.org/10.1016/j.virol.2017.12.009
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