Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease

We recently established a mouse model (288–330(+/+)) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 10(6) PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar...

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Detalles Bibliográficos
Autores principales: Douglas, Madeline G., Kocher, Jacob F., Scobey, Trevor, Baric, Ralph S., Cockrell, Adam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869108/
https://www.ncbi.nlm.nih.gov/pubmed/29277291
http://dx.doi.org/10.1016/j.virol.2017.12.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869108/
https://www.ncbi.nlm.nih.gov/pubmed/29277291
http://dx.doi.org/10.1016/j.virol.2017.12.006

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