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Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease
We recently established a mouse model (288–330(+/+)) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 10(6) PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869108/ https://www.ncbi.nlm.nih.gov/pubmed/29277291 http://dx.doi.org/10.1016/j.virol.2017.12.006 |