Cargando…

XPD–The Lynchpin of NER: Molecule, Gene, Polymorphisms, and Role in Colorectal Carcinogenesis

In mammals the bulky DNA adduct lesions known to result in deleterious phenotypes are acted upon and removed from the genomic DNA by nucleotide excision repair (NER) pathway. TFIIH multi-protein complex with its important helicase–Xeroderma Pigmentosum Protein (XPD) serves as the pivotal factor for...

Descripción completa

Detalles Bibliográficos
Autores principales: Sameer, Aga Syed, Nissar, Saniya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869190/
https://www.ncbi.nlm.nih.gov/pubmed/29616226
http://dx.doi.org/10.3389/fmolb.2018.00023