Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated

In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One of the hallmarks of kidney disease-related cardiovascular disease is intravascular macrophage inflammation, but the mechanism of the reaction with these toxins is not com...

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Detalles Bibliográficos
Autores principales: Wakamatsu, Takuya, Yamamoto, Suguru, Ito, Toru, Sato, Yoko, Matsuo, Koji, Takahashi, Yoshimitsu, Kaneko, Yoshikatsu, Goto, Shin, Kazama, Junichiro James, Gejyo, Fumitake, Narita, Ichiei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869412/
https://www.ncbi.nlm.nih.gov/pubmed/29543732
http://dx.doi.org/10.3390/toxins10030124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869412/
https://www.ncbi.nlm.nih.gov/pubmed/29543732
http://dx.doi.org/10.3390/toxins10030124

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