Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy

Drug‐induced cardiomyopathy contributes to drug attrition. We compared two pipelines of predictive modeling: (1) applying elastic net (EN) to differentially expressed genes (DEGs) of drugs; (2) applying integer linear programming (ILP) to construct each drug's signaling pathway starting from it...

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Detalles Bibliográficos
Autores principales: Messinis, Dimitris E., Melas, Ioannis N., Hur, Junguk, Varshney, Navya, Alexopoulos, Leonidas G., Bai, Jane P.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869547/
https://www.ncbi.nlm.nih.gov/pubmed/29341478
http://dx.doi.org/10.1002/psp4.12272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869547/
https://www.ncbi.nlm.nih.gov/pubmed/29341478
http://dx.doi.org/10.1002/psp4.12272

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