Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators

Translational pharmacokinetic (PK) models are needed to describe and predict drug concentration‐time profiles in lung tissue at the site of action to enable animal‐to‐man translation and prediction of efficacy in humans for inhaled medicines. Current pulmonary PK models are generally descriptive rat...

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Detalles Bibliográficos
Autores principales: Hendrickx, Ramon, Lamm Bergström, Eva, Janzén, David L. I., Fridén, Markus, Eriksson, Ulf, Grime, Ken, Ferguson, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869554/
https://www.ncbi.nlm.nih.gov/pubmed/29280349
http://dx.doi.org/10.1002/psp4.12270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869554/
https://www.ncbi.nlm.nih.gov/pubmed/29280349
http://dx.doi.org/10.1002/psp4.12270

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