Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

This study aimed to construct a physiologically based pharmacokinetic (PBPK) model of rifampicin that can accurately and quantitatively predict complex drug‐drug interactions (DDIs) involving its saturable hepatic uptake and auto‐induction. Using in silico and in vitro parameters, and reported clini...

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Detalles Bibliográficos
Autores principales: Asaumi, Ryuta, Toshimoto, Kota, Tobe, Yoshifusa, Hashizume, Kenta, Nunoya, Ken‐ichi, Imawaka, Haruo, Lee, Wooin, Sugiyama, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869557/
https://www.ncbi.nlm.nih.gov/pubmed/29368402
http://dx.doi.org/10.1002/psp4.12275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869557/
https://www.ncbi.nlm.nih.gov/pubmed/29368402
http://dx.doi.org/10.1002/psp4.12275

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