Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). EETs exert vasodilatory, anti-inflammatory, anti-apoptotic, and pro-angiogenic effects. Administration of sEH inhibitors...

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Detalles Bibliográficos
Autores principales: Tu, Ranran, Armstrong, Jillian, Lee, Kin Sing Stephen, Hammock, Bruce D., Sapirstein, Adam, Koehler, Raymond C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869703/
https://www.ncbi.nlm.nih.gov/pubmed/29588470
http://dx.doi.org/10.1038/s41598-018-23504-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869703/
https://www.ncbi.nlm.nih.gov/pubmed/29588470
http://dx.doi.org/10.1038/s41598-018-23504-1

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