Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis

Janus tyrosine kinase 3 (JAK3) is expressed in lymphoid cells and is involved in the signalling of T cell functions. The development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune disorders. In this article, we developed the 4-aminopiperidine-...

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Detalles Bibliográficos
Autores principales: Pei, Heying, He, Linhong, Shao, Mingfeng, Yang, Zhuang, Ran, Yan, Li, Dan, Zhou, Yuanyuan, Tang, Minghai, Wang, Taijin, Gong, Yanqiu, Chen, Xiaoxin, Yang, Shengyong, Xiang, Mingli, Chen, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869712/
https://www.ncbi.nlm.nih.gov/pubmed/29588471
http://dx.doi.org/10.1038/s41598-018-23569-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869712/
https://www.ncbi.nlm.nih.gov/pubmed/29588471
http://dx.doi.org/10.1038/s41598-018-23569-y

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