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Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester

Hydrolysis of organic sulfate esters proceeds by two distinct mechanisms, water attacking at either sulfur (S–O bond cleavage) or carbon (C–O bond cleavage). In primary and secondary alkyl sulfates, attack at carbon is favored, whereas in aromatic sulfates and sulfated sugars, attack at sulfur is pr...

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Detalles Bibliográficos
Autores principales: van Loo, Bert, Schober, Markus, Valkov, Eugene, Heberlein, Magdalena, Bornberg-Bauer, Erich, Faber, Kurt, Hyvönen, Marko, Hollfelder, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870055/
https://www.ncbi.nlm.nih.gov/pubmed/29458126
http://dx.doi.org/10.1016/j.jmb.2018.02.010