Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

OBJECTIVE: The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation is potentially beneficial for systemic metabolism. Pharmacological PGC-1α1 activators could be...

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Detalles Bibliográficos
Autores principales: Pettersson-Klein, A.T., Izadi, M., Ferreira, D.M.S., Cervenka, I., Correia, J.C., Martinez-Redondo, V., Southern, M., Cameron, M., Kamenecka, T., Agudelo, L.Z., Porsmyr-Palmertz, M., Martens, U., Lundgren, B., Otrocka, M., Jenmalm-Jensen, A., Griffin, P.R., Ruas, J.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870114/
https://www.ncbi.nlm.nih.gov/pubmed/29428596
http://dx.doi.org/10.1016/j.molmet.2018.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870114/
https://www.ncbi.nlm.nih.gov/pubmed/29428596
http://dx.doi.org/10.1016/j.molmet.2018.01.017

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