Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism

BACKGROUND: Cyclooxygenase-2 (COX-2), the inducible COX form, is a bi-functional membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty acid) to form 2-series of prostaglandins known to be involved in cancer development. Overexpression of COX-2 has been found in a ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Yi, Yang, Xiaoyu, Wang, Tao, Yang, Liu, He, Yu-Ying, Miskimins, Keith, Qian, Steven Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870477/
https://www.ncbi.nlm.nih.gov/pubmed/29587668
http://dx.doi.org/10.1186/s12885-018-4250-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870477/
https://www.ncbi.nlm.nih.gov/pubmed/29587668
http://dx.doi.org/10.1186/s12885-018-4250-8

Ejemplares similares