Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens

BACKGROUND: Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains (i.e. RNA-binding domain, RBD, and effector domain, ED) contribute to its various activities. MET...

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Detalles Bibliográficos
Autores principales: Trapp, Sascha, Soubieux, Denis, Lidove, Alexandra, Esnault, Evelyne, Lion, Adrien, Guillory, Vanaique, Wacquiez, Alan, Kut, Emmanuel, Quéré, Pascale, Larcher, Thibaut, Ledevin, Mireille, Nadan, Virginie, Camus-Bouclainville, Christelle, Marc, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870492/
https://www.ncbi.nlm.nih.gov/pubmed/29587792
http://dx.doi.org/10.1186/s12985-018-0960-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870492/
https://www.ncbi.nlm.nih.gov/pubmed/29587792
http://dx.doi.org/10.1186/s12985-018-0960-4

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