Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer

Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor genes, alter immune response and epigenetically re...

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Swathi, Hu, Qiang, Krishnan, Nithya, Wang, Dan, Smit, Evelyn, Granger, Victoria, Rak, Monika, Attwood, Kristopher, Johnson, Candace, Morrison, Carl, Pili, Roberto, Chatta, Gurkamal, Guru, Khurshid, Gueron, Geraldine, McNally, Lacey, Wang, Jianmin, Woloszynska-Read, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870579/
https://www.ncbi.nlm.nih.gov/pubmed/29242529
http://dx.doi.org/10.1038/s41419-017-0024-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870579/
https://www.ncbi.nlm.nih.gov/pubmed/29242529
http://dx.doi.org/10.1038/s41419-017-0024-5

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