ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line

Excess production of reactive oxygen species (ROS) is known to cause apoptotic cell death. However, the molecular mechanisms whereby ROS induce apoptosis remain elusive. Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-indu...

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Detalles Bibliográficos
Autores principales: Nishi, Kensuke, Iwaihara, Yuri, Tsunoda, Toshiyuki, Doi, Keiko, Sakata, Toshifumi, Shirasawa, Senji, Ishikura, Shuhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870588/
https://www.ncbi.nlm.nih.gov/pubmed/29242562
http://dx.doi.org/10.1038/s41419-017-0006-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870588/
https://www.ncbi.nlm.nih.gov/pubmed/29242562
http://dx.doi.org/10.1038/s41419-017-0006-7

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