In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death

In some diseases the TrkC.T1 isoform is upregulated in glia, associated with glial TNF-α production and neuronal death. What remains unknown are the activating signals in glia, and how paracrine signals may be selective for a targeted neuron while sparing other proximate neurons. We studied these qu...

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Detalles Bibliográficos
Autores principales: Galán, Alba, Jmaeff, Sean, Barcelona, Pablo F., Brahimi, Fouad, Sarunic, Marinko V., Saragovi, H. Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870594/
https://www.ncbi.nlm.nih.gov/pubmed/29242588
http://dx.doi.org/10.1038/s41419-017-0074-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870594/
https://www.ncbi.nlm.nih.gov/pubmed/29242588
http://dx.doi.org/10.1038/s41419-017-0074-8

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