cGAS surveillance of micronuclei links genome instability to innate immunity

DNA is strictly compartmentalised within the nucleus to prevent autoimmunity1; despite this cGAS, a cytosolic sensor of dsDNA, is activated in autoinflammatory disorders and by DNA damage2–6. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS...

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Detalles Bibliográficos
Autores principales: Mackenzie, Karen J., Carroll, Paula, Martin, Carol-Anne, Murina, Olga, Fluteau, Adeline, Simpson, Daniel, Olova, Nelly, Sutcliffe, Hannah, Rainger, Jacqueline, Robertson, Andrea, Osborn, Ruby, Wheeler, Ann, Nowotny, Marcin, Gilbert, Nick, Chandra, Tamir, Reijns, Martin A. M., Jackson, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870830/
https://www.ncbi.nlm.nih.gov/pubmed/28738408
http://dx.doi.org/10.1038/nature23449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870830/
https://www.ncbi.nlm.nih.gov/pubmed/28738408
http://dx.doi.org/10.1038/nature23449

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