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The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

Endoplasmic reticulum (ER) stress is transmitted to mitochondria and is associated with pathologic mitochondrial dysfunction in diverse diseases. The PERK arm of the unfolded protein response (UPR) protects mitochondria during ER stress through the transcriptional and translational remodeling of mit...

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Detalles Bibliográficos
Autores principales: Lebeau, Justine, Saunders, Jaclyn M., Moraes, Vivian W.R., Madhavan, Aparajita, Madrazo, Nicole, Anthony, Mary C., Wiseman, R. Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870888/
https://www.ncbi.nlm.nih.gov/pubmed/29539413
http://dx.doi.org/10.1016/j.celrep.2018.02.055