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Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo

BACKGROUND: Gene therapy has been developed and used in medical treatment for many years, especially for the enhancement of endothelialization and angiogenesis. But slow endosomal escape rate is still one of the major barriers to successful gene delivery. In order to evaluate whether introducing oli...

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Detalles Bibliográficos
Autores principales: Li, Qian, Hao, Xuefang, Zaidi, Syed Saqib Ali, Guo, Jintang, Ren, Xiangkui, Shi, Changcan, Zhang, Wencheng, Feng, Yakai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870920/
https://www.ncbi.nlm.nih.gov/pubmed/29580233
http://dx.doi.org/10.1186/s12951-018-0358-x