Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21

Trisomy of chromosome 21, the genetic cause of Down syndrome, has the potential to alter expression of genes on chromosome 21, as well as other locations throughout the genome. These transcriptome changes are likely to underlie the Down syndrome clinical phenotypes. We have employed RNA-seq to under...

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Detalles Bibliográficos
Autores principales: Gonzales, Patrick K., Roberts, Christine M., Fonte, Virginia, Jacobsen, Connor, Stein, Gretchen H., Link, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870938/
https://www.ncbi.nlm.nih.gov/pubmed/29584757
http://dx.doi.org/10.1371/journal.pone.0194581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870938/
https://www.ncbi.nlm.nih.gov/pubmed/29584757
http://dx.doi.org/10.1371/journal.pone.0194581

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