Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators

Prokaryotic Argonaute proteins (pAgos) have been proposed as an alternative to the CRISPR/Cas9 platform for gene editing. Although Argonaute from Natronobacterium gregoryi (NgAgo) was recently shown unable to cleave genomic DNA in mammalian cells, the utility of NgAgo or other pAgos as a targetable...

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Detalles Bibliográficos
Autores principales: O’Geen, Henriette, Ren, Chonghua, Coggins, Nicole B., Bates, Sofie L., Segal, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870970/
https://www.ncbi.nlm.nih.gov/pubmed/29584750
http://dx.doi.org/10.1371/journal.pone.0193818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870970/
https://www.ncbi.nlm.nih.gov/pubmed/29584750
http://dx.doi.org/10.1371/journal.pone.0193818

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