Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus

OBJECTIVES: Low copy numbers and deletion of complement C4 genes are potent risk factors for systemic lupus erythematosus (SLE). However, it is not known whether this genetic association affects the clinical outcome. We investigated C4 copy number variation and its relationship to clinical and serol...

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Detalles Bibliográficos
Autores principales: Jüptner, M, Flachsbart, F, Caliebe, A, Lieb, W, Schreiber, S, Zeuner, R, Franke, A, Schröder, J O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871021/
https://www.ncbi.nlm.nih.gov/pubmed/29050534
http://dx.doi.org/10.1177/0961203317735187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871021/
https://www.ncbi.nlm.nih.gov/pubmed/29050534
http://dx.doi.org/10.1177/0961203317735187

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