PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells

Prostaglandin E(2) (PGE(2)) contributes to tumor progression by promoting cancer cell growth, invasion and by creating a favorable pro-tumor microenvironment. PGE(2) has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor...

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Detalles Bibliográficos
Autores principales: Bazzani, Lorenzo, Donnini, Sandra, Giachetti, Antonio, Christofori, Gerhard, Ziche, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871088/
https://www.ncbi.nlm.nih.gov/pubmed/29599917
http://dx.doi.org/10.18632/oncotarget.24499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871088/
https://www.ncbi.nlm.nih.gov/pubmed/29599917
http://dx.doi.org/10.18632/oncotarget.24499

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