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PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells
Prostaglandin E(2) (PGE(2)) contributes to tumor progression by promoting cancer cell growth, invasion and by creating a favorable pro-tumor microenvironment. PGE(2) has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871088/ https://www.ncbi.nlm.nih.gov/pubmed/29599917 http://dx.doi.org/10.18632/oncotarget.24499 |