Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

Trib2 pseudokinase has oncogenic and tumour suppressive functions depending on the cellular context. We investigated the ability of Trib2 to transform different haemopoietic stem and progenitor cells (HSPCs). Our study identified the granulocyte-macrophage progenitor (GMP) subpopulation as a potent...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Connor, Caitriona, Yalla, Krishna, Salomé, Mara, Moka, Hothri Ananyambica, Castañeda, Eduardo Gómez, Eyers, Patrick A., Keeshan, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871090/
https://www.ncbi.nlm.nih.gov/pubmed/29599919
http://dx.doi.org/10.18632/oncotarget.24525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871090/
https://www.ncbi.nlm.nih.gov/pubmed/29599919
http://dx.doi.org/10.18632/oncotarget.24525

Ejemplares similares