Cargando…

Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2

Trib2 pseudokinase has oncogenic and tumour suppressive functions depending on the cellular context. We investigated the ability of Trib2 to transform different haemopoietic stem and progenitor cells (HSPCs). Our study identified the granulocyte-macrophage progenitor (GMP) subpopulation as a potent...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Connor, Caitriona, Yalla, Krishna, Salomé, Mara, Moka, Hothri Ananyambica, Castañeda, Eduardo Gómez, Eyers, Patrick A., Keeshan, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871090/ https://www.ncbi.nlm.nih.gov/pubmed/29599919 http://dx.doi.org/10.18632/oncotarget.24525

Ejemplares similares

A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling
por: Salomé, Mara, et al.
Publicado: (2018)

TRIB2 regulates normal and stress-induced thymocyte proliferation
por: Liang, Kai Ling, et al.
Publicado: (2016)

Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C
por: Liang, Kai Ling, et al.
Publicado: (2016)

Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond
por: McMillan, Hamish D, et al.
Publicado: (2021)

Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo
por: Onai, Nobuyuki, et al.
Publicado: (2020)

Granulocyte function in myeloblastic leukaemia.
por: Wilkinson, P. M., et al.
Publicado: (1975)

Mathematical Analysis of Cytokine-Induced Differentiation of Granulocyte-Monocyte Progenitor Cells
por: Weston, Bronson R., et al.
Publicado: (2018)

Thyroid Tumours,Lymphomas, Granulocytic Leukaemia
por: Duthie, M. B., et al.
Publicado: (1973)

Busulphan in the Treatment of Chronic Granulocytic Leukaemia
por: Bridges, J. M., et al.
Publicado: (1961)

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
por: Chaudhury, Shahzya, et al.
Publicado: (2018)

The sensitivity to hyperthermia of human granulocyte/macrophage progenitor cells (CFU-GM) derived from blood or marrow of normal subjects and patients with chronic granulocytic leukaemia.
por: Blackburn, M. J., et al.
Publicado: (1984)

Acute Monocytic Leukæmia
por: Biggart, J. Henry
Publicado: (1945)

The Critical Role of TRIB2 in Cancer and Therapy Resistance
por: Mayoral-Varo, Victor, et al.
Publicado: (2021)

The Impact of Integrin β2 on Granulocyte/Macrophage Progenitor Proliferation
por: Zhang, Li‐Jie, et al.
Publicado: (2019)

Investigating the response of paediatric leukaemia‐propagating cells to BCL‐2 inhibitors
por: Diamanti, Paraskevi, et al.
Publicado: (2020)

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease
por: Eyers, Patrick A., et al.
Publicado: (2017)

Effects of recombinant human granulocyte colony-stimulating factor (G-CSF) on blast progenitors from acute myeloblastic leukaemia patients.
por: Nara, N., et al.
Publicado: (1987)

Some Biochemical Aspects of Leukaemias: The Appearance of a Soluble Disulphide in the Blood in Chronic Granulocytic Leukaemia
por: Harrap, K. R., et al.
Publicado: (1964)

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL
por: Stein, Sarah J., et al.
Publicado: (2016)

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance
por: Machado, Susana, et al.
Publicado: (2020)

TRIB2 safeguards naive T cell homeostasis during aging
por: Cao, Wenqiang, et al.
Publicado: (2023)

The Skin Lesions of Monocytic Leukaemia
por: Fairburn, E. A., et al.
Publicado: (1947)

Acute Monocytic Leukæmia in Indians
por: Napier, L. Everard, et al.
Publicado: (1943)

Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia
por: Irvine, David A., et al.
Publicado: (2016)

Significance of non-standard Philadelphia chromosomes in chronic granulocytic leukaemia.
por: Potter, A. M., et al.
Publicado: (1981)

Calcium and Calcineurin-NFAT Signaling Regulate Granulocyte-Monocyte Progenitor Cell Cycle via Flt3-L
por: Fric, Jan, et al.
Publicado: (2014)

The maintenance of busulphan-induced remissions in chronic granulocytic leukaemia with recombinant interferon alpha-2b.
por: Bergsagel, D. E., et al.
Publicado: (1990)

Transcriptional signatures of the BCL2 family for individualized acute myeloid leukaemia treatment
por: Lee, Chansub, et al.
Publicado: (2022)

PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling
por: Hay, Jodie, et al.
Publicado: (2022)

Emerging roles of infiltrating granulocytes and monocytes in homeostasis
por: Groeneweg, Linda, et al.
Publicado: (2020)

Functional analysis of granulocyte and monocyte subpopulations in neonates
por: Hegge, Ines, et al.
Publicado: (2019)

TRIB2 contributes to cisplatin resistance in small cell lung cancer
por: Liang, Yuanxin, et al.
Publicado: (2017)

Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia
por: Aung, Myint Myat Khine, et al.
Publicado: (2021)

Evidence of seasonality in the diagnosis of monocytic leukaemia
por: Eatough, J P
Publicado: (2002)

Successful pregnancy in acute monocytic leukaemia.
por: Gokal, R., et al.
Publicado: (1976)

A Case of Acute Monocytic Leukæmia
por: Nayak, K. V.
Publicado: (1943)

Monocytic Leukaemia: Report of Four Cases
por: Kennedy, Arthur C., et al.
Publicado: (1950)

Cytogenetic evolution and clonal proliferation in acute transformation of chronic granulocytic leukaemia.
por: Spiers, A. S., et al.
Publicado: (1968)

Trib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiency
por: Do, Eun Kyoung, et al.
Publicado: (2017)

Expression and Related Mechanisms of miR-100 and TRIB2 in COPD Patients
por: Mai, Zhitao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_06kc9h4d6kltvd1bb56637ajtv