High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc28(CDK1)

Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to...

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Detalles Bibliográficos
Autores principales: Maya Miles, Douglas, Peñate, Xenia, Sanmartín Olmo, Trinidad, Jourquin, Frederic, Muñoz Centeno, Maria Cruz, Mendoza, Manuel, Simon, Marie-Noelle, Chavez, Sebastian, Geli, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871333/
https://www.ncbi.nlm.nih.gov/pubmed/29580382
http://dx.doi.org/10.7554/eLife.35337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871333/
https://www.ncbi.nlm.nih.gov/pubmed/29580382
http://dx.doi.org/10.7554/eLife.35337

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