SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. However, less is known about the upstream regulators of the RPs. Here, we identify SPIN1 (Spindlin 1) as a novel binding partner of human RPL5/uL18 that is important for this pathway. SPIN1 ablation activates p53, supp...

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Detalles Bibliográficos
Autores principales: Fang, Ziling, Cao, Bo, Liao, Jun-Ming, Deng, Jun, Plummer, Kevin D, Liao, Peng, Liu, Tao, Zhang, Wensheng, Zhang, Kun, Li, Li, Margolin, David, Zeng, Shelya X, Xiong, Jianping, Lu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871334/
https://www.ncbi.nlm.nih.gov/pubmed/29547122
http://dx.doi.org/10.7554/eLife.31275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871334/
https://www.ncbi.nlm.nih.gov/pubmed/29547122
http://dx.doi.org/10.7554/eLife.31275

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