11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation

Chronically elevated glucocorticoid levels impair cognition and are pro-inflammatory in the brain. Deficiency or inhibition of 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1), which converts inactive into active glucocorticoids, protects against glucocorticoid-associated chronic stress- or age-re...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Manu, Kipari, Tiina M.J., Zhang, Zhenguang, Man, Tak Yung, Forster, Thorsten, Homer, Natalie Z.M., Seckl, Jonathan R., Holmes, Megan C., Chapman, Karen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871395/
https://www.ncbi.nlm.nih.gov/pubmed/29162555
http://dx.doi.org/10.1016/j.bbi.2017.11.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871395/
https://www.ncbi.nlm.nih.gov/pubmed/29162555
http://dx.doi.org/10.1016/j.bbi.2017.11.015

Ejemplares similares