Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2

Individuals with the rare developmental disorder fibrodysplasia ossificans progressiva (FOP) experience disabling heterotopic ossification caused by a gain of function mutation in the intracellular region of the BMP type I receptor kinase ALK2, encoded by the gene ACVR1. Small molecule BMP type I re...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, Eleanor, Bullock, Alex N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871398/
https://www.ncbi.nlm.nih.gov/pubmed/28918311
http://dx.doi.org/10.1016/j.bone.2017.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871398/
https://www.ncbi.nlm.nih.gov/pubmed/28918311
http://dx.doi.org/10.1016/j.bone.2017.09.004

Ejemplares similares