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Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2
Individuals with the rare developmental disorder fibrodysplasia ossificans progressiva (FOP) experience disabling heterotopic ossification caused by a gain of function mutation in the intracellular region of the BMP type I receptor kinase ALK2, encoded by the gene ACVR1. Small molecule BMP type I re...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871398/ https://www.ncbi.nlm.nih.gov/pubmed/28918311 http://dx.doi.org/10.1016/j.bone.2017.09.004 |