A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target

Aberrant DNA methylation mediated by deregulation of DNA methyltransferases (DNMT) is a key hallmark of acute myeloid leukemia (AML), yet efforts to target DNMT deregulation for drug development have lagged. We previously demonstrated that upregulation of fatty acid-binding protein 4 (FABP4) promote...

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Detalles Bibliográficos
Autores principales: Yan, F, Shen, N, Pang, JX, Zhao, N, Zhang, YW, Bode, AM, Al-Kali, A, Litzow, MR, Li, B, Liu, SJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871544/
https://www.ncbi.nlm.nih.gov/pubmed/28993705
http://dx.doi.org/10.1038/leu.2017.307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871544/
https://www.ncbi.nlm.nih.gov/pubmed/28993705
http://dx.doi.org/10.1038/leu.2017.307

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