Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression

Genomic loss of 5-hydroxymethylcytosine (5hmC) accompanies malignant cellular transformation in breast cancer. Vitamin C serves as a cofactor for TET methylcytosine dioxygenases to increase 5hmC generation. Here we show that the transcription of SVCT2, a major vitamin C transporter, was decreased in...

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Detalles Bibliográficos
Autores principales: Sant, David W., Mustafi, Sushmita, Gustafson, Christopher B., Chen, Joshua, Slingerland, Joyce M., Wang, Gaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871772/
https://www.ncbi.nlm.nih.gov/pubmed/29593282
http://dx.doi.org/10.1038/s41598-018-23714-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871772/
https://www.ncbi.nlm.nih.gov/pubmed/29593282
http://dx.doi.org/10.1038/s41598-018-23714-7

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