USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective degradation of gain-of-function p53 mutants has emerged as a highly attractive therapeutic strategy to target cancer cells harboring specific p53 m...

Descripción completa

Detalles Bibliográficos
Autores principales: Padmanabhan, Achuth, Candelaria, Nicholes, Wong, Kwong-Kwok, Nikolai, Bryan C., Lonard, David M., O’Malley, Bert W., Richards, JoAnne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871815/
https://www.ncbi.nlm.nih.gov/pubmed/29593334
http://dx.doi.org/10.1038/s41467-018-03599-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871815/
https://www.ncbi.nlm.nih.gov/pubmed/29593334
http://dx.doi.org/10.1038/s41467-018-03599-w

Ejemplares similares