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Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release
AIM: To explore hepatitis C virus (HCV) adaptive mutations or combinations thereof responsible for enhanced viral production and investigate the underlying mechanisms. METHODS: A series of plasmids with adaptive mutations were constructed. After the plasmids were transfected into Huh7.5 cells, we de...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871825/ https://www.ncbi.nlm.nih.gov/pubmed/29599605 http://dx.doi.org/10.3748/wjg.v24.i12.1299 |