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Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release

AIM: To explore hepatitis C virus (HCV) adaptive mutations or combinations thereof responsible for enhanced viral production and investigate the underlying mechanisms. METHODS: A series of plasmids with adaptive mutations were constructed. After the plasmids were transfected into Huh7.5 cells, we de...

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Detalles Bibliográficos
Autores principales:	Wang, Qi, Li, Yue, Liu, Shun-Ai, Xie, Wen, Cheng, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2018
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871825/ https://www.ncbi.nlm.nih.gov/pubmed/29599605 http://dx.doi.org/10.3748/wjg.v24.i12.1299

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