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First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD

Gram-positive bacteria homeostasis and antibiotic resistance mechanisms are dependent on the intricate architecture of the cell wall, where amidated peptidoglycan plays an important role. The amidation reaction is carried out by the bi-enzymatic complex MurT-GatD, for which biochemical and structura...

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Detalles Bibliográficos
Autores principales: Leisico, Francisco, V. Vieira, Diana, Figueiredo, Teresa A., Silva, Micael, Cabrita, Eurico J., Sobral, Rita G., Ludovice, Ana Madalena, Trincão, José, Romão, Maria João, de Lencastre, Hermínia, Santos-Silva, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871853/
https://www.ncbi.nlm.nih.gov/pubmed/29593310
http://dx.doi.org/10.1038/s41598-018-22986-3