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First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD
Gram-positive bacteria homeostasis and antibiotic resistance mechanisms are dependent on the intricate architecture of the cell wall, where amidated peptidoglycan plays an important role. The amidation reaction is carried out by the bi-enzymatic complex MurT-GatD, for which biochemical and structura...
Autores principales: | Leisico, Francisco, V. Vieira, Diana, Figueiredo, Teresa A., Silva, Micael, Cabrita, Eurico J., Sobral, Rita G., Ludovice, Ana Madalena, Trincão, José, Romão, Maria João, de Lencastre, Hermínia, Santos-Silva, Teresa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871853/ https://www.ncbi.nlm.nih.gov/pubmed/29593310 http://dx.doi.org/10.1038/s41598-018-22986-3 |
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