Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of hum...

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Detalles Bibliográficos
Autores principales: Marteil, Gaëlle, Guerrero, Adan, Vieira, André F., de Almeida, Bernardo P., Machado, Pedro, Mendonça, Susana, Mesquita, Marta, Villarreal, Beth, Fonseca, Irina, Francia, Maria E., Dores, Katharina, Martins, Nuno P., Jana, Swadhin C., Tranfield, Erin M., Barbosa-Morais, Nuno L., Paredes, Joana, Pellman, David, Godinho, Susana A., Bettencourt-Dias, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871873/
https://www.ncbi.nlm.nih.gov/pubmed/29593297
http://dx.doi.org/10.1038/s41467-018-03641-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871873/
https://www.ncbi.nlm.nih.gov/pubmed/29593297
http://dx.doi.org/10.1038/s41467-018-03641-x

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