A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

The hemagglutinin (HA) receptor-binding site (RBS) in human influenza A viruses is critical for attachment to host cells, which imposes a functional constraint on its natural evolution. On the other hand, being part of the major antigenic sites, the HA RBS of human H3N2 viruses needs to constantly m...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Nicholas C., Thompson, Andrew J., Xie, Jia, Lin, Chih-Wei, Nycholat, Corwin M., Zhu, Xueyong, Lerner, Richard A., Paulson, James C., Wilson, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871881/
https://www.ncbi.nlm.nih.gov/pubmed/29593268
http://dx.doi.org/10.1038/s41467-018-03663-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871881/
https://www.ncbi.nlm.nih.gov/pubmed/29593268
http://dx.doi.org/10.1038/s41467-018-03663-5

Ejemplares similares