Structural alterations by five disease-causing mutations in the low-pH conformation of human dihydrolipoamide dehydrogenase (hLADH) analyzed by molecular dynamics – Implications in functional loss and modulation of reactive oxygen species generation by pathogenic hLADH forms

Human dihydrolipoamide dehydrogenase (hLADH) is a flavoenzyme component (E3) of the human alpha-ketoglutarate dehydrogenase complex (α-KGDHc) and few other dehydrogenase complexes. Pathogenic mutations of hLADH cause severe metabolic diseases (atypical forms of E3 deficiency) that often escalate to...

Descripción completa

Detalles Bibliográficos
Autores principales: Ambrus, Attila, Mizsei, Reka, Adam-Vizi, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871931/
https://www.ncbi.nlm.nih.gov/pubmed/29594200
http://dx.doi.org/10.1016/j.bbrep.2015.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871931/
https://www.ncbi.nlm.nih.gov/pubmed/29594200
http://dx.doi.org/10.1016/j.bbrep.2015.04.006

Ejemplares similares