Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells

Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of autoreactive thymocytes. Although dendritic cells (DC) reinforce this process by transporting innocuous peripheral self-antigens, the mechanisms that control their thymic entry remain unclear. Here we show that mTEC-CD4(+) thymo...

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Detalles Bibliográficos
Autores principales: Lopes, Noëlla, Charaix, Jonathan, Cédile, Oriane, Sergé, Arnauld, Irla, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872006/
https://www.ncbi.nlm.nih.gov/pubmed/29593265
http://dx.doi.org/10.1038/s41467-018-03619-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872006/
https://www.ncbi.nlm.nih.gov/pubmed/29593265
http://dx.doi.org/10.1038/s41467-018-03619-9

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