The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation

BACKGROUND: The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. In patients, inactivating mutations in samhd1 are associated with the autoimmune...

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Detalles Bibliográficos
Autores principales: Herrmann, Alexandra, Wittmann, Sabine, Thomas, Dominique, Shepard, Caitlin N., Kim, Baek, Ferreirós, Nerea, Gramberg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872582/
https://www.ncbi.nlm.nih.gov/pubmed/29610582
http://dx.doi.org/10.1186/s13100-018-0116-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872582/
https://www.ncbi.nlm.nih.gov/pubmed/29610582
http://dx.doi.org/10.1186/s13100-018-0116-5

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